![]() ![]() In other words, the defensive action of antibody cross-reactivity imparts a broader immunity against pathogens or provides cross-protective immunity to related The cross-reactive antibody provides cross-protective immunity to related pathogen strains orĪntigenic variants in natural epidemiology. The Biological Significance of Cross-reactivityĬross-reactivity of antibodies shows both defensive and offensive properties. To some extent, cross-reactivity greatly reduces specificity.ģ. While cross-reactivity assesses the degree to which different antigens resemble the immune Specificity evaluates the extent to which the immune system distinguishes between different antigens. In immunoassays, cross-reactivity ofĪntibody (polyclonal antibody) enhances the sensitivity of the result and allows for the detection of antigens with low abundance. It is the most prominent feature of immune response and is the basic basis for the prevention and diagnosis inĬross-reactivity refers to a situation in which an antibody recognizes and binds to two or more antigens that are highly homologous or possess the same epitope. The specificityĮnables to precisely detect a target antigen thus avoiding measurement of impostor antigens. The specificity is determined by the types, arrangement order, and spatial configuration of epitope(s) on the antigen. Noted that this unique epitope may be present on more than one antigen. In immunology, specificity refers to the ability of paratopes on an antibody to recognize and interact with only a single epitope on the corresponding antigen. The Association and Difference between Cross-Reactivity and Specificity ![]()
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